Peer-reviewed veterinary case report
Endocannabinoid system protects against cryptogenic seizures.
- Journal:
- Pharmacological reports : PR
- Year:
- 2011
- Authors:
- van Rijn, Clementina M et al.
- Affiliation:
- Donders Institute for Brain · Netherlands
- Species:
- rodent
Abstract
Effects of the cannabinoid antagonist rimonabant on the EEG were investigated in healthy, non-epileptic rats. The drug was administered orally at 30 mg/kg/day for 3 weeks. The EEG was recorded continuously. In 3 out of 13 rats, limbic convulsive seizures, which were not related to the time of drug administration, were observed after 5-8 days. We hypothesize that an accumulation of micro-injuries in the brain is responsible for these "spontaneous" seizures.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21441624/