Peer-reviewed veterinary case report
Single application of a CB1 receptor antagonist rapidly following head injury prevents long-term hyperexcitability in a rat model.
- Journal:
- Epilepsy research
- Year:
- 2009
- Authors:
- Echegoyen, Julio et al.
- Affiliation:
- Department of Anatomy and Neurobiology · United States
- Species:
- rodent
Abstract
Effective prophylaxis for post-traumatic epilepsy currently does not exist, and clinical trials using anticonvulsant drugs have yielded no long-term antiepileptogenic effects. We report that a single, rapid post-traumatic application of the proconvulsant cannabinoid type-1 (CB1) receptor antagonist SR141716A (Rimonabant-Acomplia) abolishes the long-term increase in seizure susceptibility caused by head injury in rats. These results indicate that, paradoxically, a seizure-enhancing drug may disrupt the epileptogenic process if applied within a short therapeutic time window.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19369036/