Peer-reviewed veterinary case report
Early kidney injury signs in Beagle dogs with endotoxemia
By Steblaj, B et al.·Published in Research in veterinary science·2023·Department of Clinical Diagnostics and Services·View original on PubMed →
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Original publication title: Endotoxic kidney injury in Beagle dogs assessed by serum creatinine and symmetric dimethylarginine, and urinary neutrophil gelatinase-associated lipocalin and clusterin.
- Species:
- dog
Plain-English summary
A group of six Beagle dogs developed kidney injury after being exposed to a bacterial infection that caused endotoxemia. The dogs showed signs of acute kidney injury, with three of them reaching a significant stage of kidney damage. Blood and urine tests revealed increases in certain markers, indicating kidney stress before traditional tests like serum creatinine showed changes. This study suggests that monitoring specific urine and blood markers can help detect kidney injury earlier, allowing for quicker treatment.
People also search for: Beagle kidney injury symptoms · dog kidney disease treatment · early signs of kidney problems in dogs
Abstract
Sepsis of Gram negative bacterial origin results in lipopolysaccharide-induced endotoxemia. This often leads to acute kidney injury (AKI) and its recognition remains a challenge and delays treatment. As renal damage occurs before a rise in serum creatinine is detected, new early biomarkers of kidney injury need to be explored. The aim of this study was to determine changes in serum parameters of renal function and urine biomarkers of renal injury. This was a descriptive study. Endotoxemia was induced intravenously in six anaesthetized Beagles (T1). To achieve normotension, dogs received fluids (T2), followed by a continuous infusion of noradrenaline and dexmedetomidine or 0.9% NaCl (T3). Ten minutes later, the dogs received fluids (T4) and noradrenaline and dexmedetomidine or 0.9% NaCl in a crossover manner (T5). At each timepoint, blood and urine were collected for serum creatinine, urea, symmetric dimethylarginine, urine protein/creatinine (UPC) ratio, urine neutrophil-gelatinase-associated lipocalin (U-NGAL), U-NGAL/creatinine ratio, urine clusterin (U-clusterin) and U-clusterin/creatinine ratio. Data were analyzed using a mixed-effect model taking into account time and stage of veterinary AKI (VAKI). Three of six dogs had a VAKI stage ≥1; one with anuria and elevated creatinine. Serum creatinine (P < 0.001), U-NGAL/creatinine ratio (P = 0.01) and U-clusterin/creatinine ratio increased over time (P < 0.01). The UPC ratio (mean (range) 0.68 (0.35-2.3) versus 0.39 (0.15-0.71) P < 0.01) and U-NGAL (3164 pg/mL (100-147,555) versus 100 (100-14,524), P = 0.01) were higher in VAKI stage ≥1 versus stage 0, respectively. Endotoxemia induced VAKI stage ≥1 in half of the dogs. Repeated measurement of selected parameters could detect AKI early.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37516042/