Peer-reviewed veterinary case report
Environmental factors linked to lymphoma risk in Golden Retrievers
By Luethcke, Kristofer R. et al.·Published in Canine Medicine and Genetics·2022·View original on Crossref →
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Original publication title: Environmental exposures and lymphoma risk: a nested case–control study using the Golden Retriever Lifetime Study cohort
- Species:
- dog
Plain-English summary
A study looked at the risk of lymphoma, a common cancer in Golden Retrievers, and how it might be linked to environmental pollution. Researchers compared 49 Golden Retrievers with lymphoma to 98 without cancer, examining their proximity to pollution sources like chemical plants and landfills, as well as factors like secondhand smoke exposure. While no strong links were found overall, there was a suggestion that living near multiple pollution sources might increase the risk of multicentric lymphoma. More research is needed to understand the connection between environmental factors and different types of lymphoma in dogs.
People also search for: Golden Retriever lymphoma risk · environmental pollution and dog cancer · how does secondhand smoke affect dogs
Abstract
AbstractLymphoma is the second most common cancer affecting Golden Retrievers and is hypothesized to arise through a complex interaction of genetic and environmental factors. The aim of this nested case–control study was to investigate the association between potential environmental pollutant sources and lymphoma risk among Golden Retrievers participating in the Golden Retriever Lifetime Study. Forty-nine Golden Retrievers with non-cutaneous lymphoma and 98 Golden Retrievers without a history of cancer matched by age, sex and neuter status were selected from the Golden Retriever Lifetime Study cohort. Geographic proximity between each dog’s primary residence and nine potential sources of environmental pollution was determined. In addition, the average annual ozone and airborne fine particulate matter levels for each dog’s county of residence and owner-reported secondhand smoke exposure were evaluated. Environmental pollution sources of interest included chemical plants, municipal dumps, manufacturing plants, incineration plants, railroad embankment tracks, landfills, coal plants, high-voltage transmission lines, and nuclear power plants. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for each exposure of interest. Subgroup analyses were conducted to evaluate whether associations differed among 1) dogs with multicentric lymphoma, 2) dogs with B-cell lymphoma, and 3) dogs with T-cell lymphoma. No variables reached statistical significance when evaluating all cases together. However, cumulative exposure burden (household proximity to 3 or more pollution sources) approached significance within the multicentric lymphoma subgroup (OR = 2.60, 95%CI 0.99–6.86, p-value = 0.053). Patterns emerged among B- and T-cell subgroups, but none reached statistical significance. Ongoing research is warranted to discern if different environmental mechanisms may be driving B- and T-cell lymphoma immunophenotypes, consistent with previously reported regional differences in subtype prevalence.
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Search related cases →Original publication on Crossref: https://doi.org/10.1186/s40575-022-00122-9