Peer-reviewed veterinary case report
Equine adenovirus 1 isolated from cauda equina neuritis.
- Journal:
- Research in veterinary science
- Year:
- 1984
- Authors:
- Edington, N et al.
- Species:
- horse
Plain-English summary
In a study involving three horses with cauda equina neuritis, a condition affecting the nerves at the lower end of the spinal cord, researchers found equine adenovirus 1 in two of the cases after several tests. They also tested spinal cord samples from six healthy horses, but did not find the virus there. All three affected horses had antibodies against a specific nerve protein, which suggests an immune response may be involved. However, the virus was not found in the nerve tissue itself. Overall, the treatment did not lead to a clear understanding of the virus's role in this condition.
Abstract
Equine adenovirus 1 was recovered after four to six passages from two out of three cases of cauda equina neuritis (CEN) using kidney monolayers. Similar treatment of lumbo-sacral spinal cord from six normal horses did not yield adenovirus. All three cases of CEN had antibodies to the neuritogenic myelin protein P2 while immunofluorescence demonstrated that autologous IgG bound to the myelin of affected nerves. Adenovirus was not detected in neural tissue by immunofluorescence.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/6390592/