Peer-reviewed veterinary case report
Equine Idiopathic Systemic Granulomatous Disease With Manifestation in the Cerebellum Associated With Equid Gammaherpesvirus 2.
- Journal:
- Journal of equine veterinary science
- Year:
- 2020
- Authors:
- Nolte, Laura Caroline et al.
- Affiliation:
- Department of Pathology · Germany
- Species:
- horse
Plain-English summary
A 15-year-old Hanoverian mare was diagnosed with a rare condition called idiopathic systemic granulomatous disease (ISGD), which can cause skin problems and inflammation in various organs. She had been losing weight for four months, had recurrent fevers, skin lesions, and trouble moving. Tests showed inflammation in her skin, lymph nodes, and brain, specifically in an area called the cerebellum. Further testing found a virus called equid gammaherpesvirus 2 in her brain tissue. This case is notable because it shows ISGD affecting both the skin and the brain at the same time.
Abstract
Idiopathic systemic granulomatous disease (ISGD), also known as equine sarcoidosis is an uncommon disease of horses, manifesting in exfoliative dermatitis and granulomatous inflammation in various organs. The current report presents a case of a 15-year-old Hanoverian mare with a 4-month history of weight loss, recurrent fever, skin lesions, and movement disorders. Pathological examination revealed granulomatous and necrotizing inflammation in the skin, regional lymph nodes, and cerebellum. Based on histological, immunohistochemical, and microbiological findings, the diagnosis of ISGD was made. Sequencing of the polymerase chain reaction product of pooled brain tissue revealed the presence of equid gammaherpesvirus 2 DNA. This case is the first description of generalized ISGD with granulomatous dermatitis simultaneously affecting the skin and cerebellum.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/33077072/