Peer-reviewed veterinary case report
Establishment of a new animal model of metabolic syndrome: SHRSP fatty (fa/fa) rats.
- Journal:
- Clinical and experimental pharmacology & physiology
- Year:
- 2004
- Authors:
- Hiraoka-Yamamoto, Junko et al.
- Affiliation:
- Mukogawa Women's University · Japan
- Species:
- rodent
Abstract
1. We established a new animal model of metabolic syndrome, SHRSP fatty (fa/fa) rats, by crossing stroke-prone spontaneously hypertensive rats of the Izumo strain (SHRSP/Izm) to Zucker fatty (ZF) (fa/fa) rats. 2. The SHRSP fatty (fa/fa) rats have a missense mutation of the leptin receptor gene and plasma leptin concentrations are augmented. The SHRSP fatty (fa/fa) rats develop obesity and hypertension simultaneously. 3. Plasma metabolic parameters, including glucose, insulin and total cholesterol and triglyceride levels, were markedly elevated in SHRSP fatty (fa/fa) rats compared with SHRSP/Izm rats. Plasma triglyceride concentrations in SHRSP fatty (fa/fa) rats were significantly elevated compared with those in ZF (fa/fa) rats. The weight of adipose tissues in SHRSP fatty (fa/fa) rats was greater than that of SHRSP/Izm rats. The phenotype of SHRSP fatty (fa/fa) rats is similar to that of human metabolic syndrome.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/14756693/