Peer-reviewed veterinary case report
Chemotherapy with lomustine, procarbazine, and prednisolone
By Tanis, J-B et al.·Published in Veterinary and comparative oncology·2018·Department of Small Animal Clinical Science, United Kingdom·View original on PubMed →
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Original publication title: Evaluation of a multi-agent chemotherapy protocol combining lomustine, procarbazine and prednisolone (LPP) for the treatment of relapsed canine non-Hodgkin high-grade lymphomas.
- Species:
- dog
Plain-English summary
A group of dogs with relapsed high-grade lymphoma were treated with a new chemotherapy protocol that combined lomustine, procarbazine, and prednisolone, but did not include vincristine. Out of 41 dogs, 25 responded well to the treatment, with some achieving complete remission. The dogs that responded had a longer time before needing to stop treatment compared to those who didn't respond. While some dogs experienced side effects like low white blood cell counts and gastrointestinal issues, the overall effectiveness and safety of this new protocol were promising.
People also search for: dog lymphoma treatment options · canine chemotherapy side effects · lomustine for dogs lymphoma
Abstract
The standard of care treatment for canine lymphoma is multi-agent chemotherapy containing prednisolone, cyclophosphamide, vincristine and an anthracycline such as doxorubicin (CHOP) or epirubicin (CEOP). Lomustine, vincristine, procarbazine, and prednisone (LOPP) has been evaluated as a rescue, with encouraging results; however, resistance to vincristine is likely in patients relapsing on CHOP/CEOP, and this agent may enhance LOPP toxicity without improving efficacy. The aim of this study was to evaluate responses to a modified-LOPP protocol that does not include vincristine (LPP) and is administered on a 21-day cycle. Medical records of dogs with high-grade multicentric lymphoma from 2012 to 2017 were reviewed. Dogs with relapsed lymphoma that received LPP as a rescue protocol were enrolled. Response, time from initiation to discontinuation (TTD) and toxicity of LPP were assessed. Forty-one dogs were included. Twenty-five dogs (61%) responded to LPP including 12 complete responses (CR) and 13 partial responses (PR). Responders had a significantly longer TTD (P < .001) compared to non-responders with 84 days for CR and 58 days for PR. Neutropenia was documented in 20 dogs (57%): 12 grade I to II, 8 grade III to IV. Thrombocytopenia was infrequent (20%): 5 grade I to II, 2 grade III to IV. Twelve dogs developed gastrointestinal toxicity (30%): 10 grade I to II and 2 grade III. Nineteen dogs had elevated ALT (59%): 9 grade I to II, 10 grade III to IV. Treatment was discontinued due to toxicity in 8 dogs (19%). The LPP protocol shows acceptable efficacy and toxicity-profile and minimizes in-hospital procedures.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29380942/