Peer-reviewed veterinary case report
Evaluation of calcium dobesilate for its anti-cataract potential in experimental animal models.
- Journal:
- Methods and findings in experimental and clinical pharmacology
- Year:
- 2010
- Authors:
- Velpandian, T et al.
- Affiliation:
- Department of Ocular Pharmacology and Pharmacy · India
Abstract
The present study evaluated the protective action of calcium dobesilate (CDO) in various experimental models of cataract. CDO was studied in hydrocortisone-induced cataract in developing chick embryos and selenite-induced cataract in pups. CDO anti-cataract activity was also evaluated after oral and topical application as eye drops in galactose (30%) fed rats. This study was further extended to evaluate the intraocular penetration of a single dose of 1% CDO (50 microL) in rabbits. CDO exhibited significant protection against cataract in experimental models and considerable penetration after single topical application. Anti-cataract activity may be due to its antioxidant as well as aldose reductase inhibitor properties. Further studies are in progress to evaluate its clinical efficacy in diabetic cataract.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20448859/