Peer-reviewed veterinary case report
Outcomes and factors in dogs with lymphoma after first rescue chemo
By Blaxill, John E & Bennett, Peter F·Published in Veterinary and comparative oncology·2024·Small Animal Specialist Hospital, United Kingdom·View original on PubMed →
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Original publication title: Evaluation of clinical response and prognostic factors in canine multicentric lymphoma treated with first rescue therapy.
- Species:
- dog
Plain-English summary
A group of dogs with multicentric lymphoma (a type of cancer affecting the lymph nodes) were treated with various chemotherapy protocols after their initial treatment failed. While many dogs responded well to the first rescue therapy, the average time before the cancer progressed again was about 56 days. Factors that seemed to improve outcomes included achieving a complete response to the first rescue treatment, using a specific chemotherapy combination (CHOP-like), and including prednisolone in the treatment plan. Unfortunately, most dogs experienced side effects during treatment, indicating a need for better therapies to help these pets achieve longer-lasting remission.
People also search for: dog lymphoma treatment options · canine cancer chemotherapy side effects · multicentric lymphoma prognosis in dogs
Abstract
Despite an initial strong response in most dogs with multicentric lymphoma treated with chemotherapy, relapse remains common. There is no clearly superior first rescue protocol described either for resistant or relapsed canine multicentric lymphoma. The objectives of this study were to assess clinical response and outcomes for canine multicentric lymphoma treated with first rescue protocols. The secondary objective was to assess prognostic variables for dogs undergoing these protocols. This was a bi-institutional retrospective cohort study. Two hundred and sixty-five dogs were treated with first rescue chemotherapy, including anthracycline-based combination chemotherapy (CHOP-like, n = 50), nitrosourea alkylating agent-rich chemotherapy (n = 45), anthracycline-based or related compound chemotherapy (n = 34), or nitrosourea single-agent chemotherapy (n = 136). The overall median progression free survival time of first rescue protocol was 56.0 days (0-455 days). Important prognostic factors identified for first rescue protocol included the attainment of a complete response to the first rescue chemotherapy (p < .001), the use of a CHOP-like first rescue protocol (p = .009), duration of first remission (HR 0.997, p = .028), and if prednisolone was included in the first rescue protocol (HR 0.41, p = .003). Adverse events (AE) were common, with 81.1% of dogs experiencing at least one AE during first rescue chemotherapy. This study highlights the need for improved first rescue therapies to provide durable remission in canine resistant or relapsed lymphoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38646859/