Peer-reviewed veterinary case report
Are lymphoma cells the same in different places in dogs with skin
By Keating, M. Kelly et al.·Published in Veterinary Dermatology·2022·Animal Dermatology Group, Inc Tustin CA USA, United States·View original on Crossref →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Evaluation of clonality from multiple anatomic sites in canine epitheliotropic T cell lymphoma
- Species:
- dog
Plain-English summary
A group of 14 dogs diagnosed with a type of skin cancer called epitheliotropic cutaneous T-cell lymphoma (eCTCL) had skin lesions in multiple areas. Tests showed that the same cancerous cells were present in all the skin samples from each dog, indicating that the cancer originated from the same source. However, in the blood, some dogs had different cancer cell clones, suggesting that these cells can move around the body rather than staying in one place. This information can help veterinarians understand how this type of cancer behaves and how to treat it effectively.
People also search for: dog skin cancer treatment · epitheliotropic cutaneous T-cell lymphoma in dogs · dog cancer symptoms skin lesions
Abstract
AbstractBackground: Canine epitheliotropic cutaneous T‐cell lymphoma (eCTCL) is thought to represent a disease homologue to human mycosis fungoides (MF). In human MF, neoplastic cells are phenotypically consistent with resident effector memory T cells, a population that remains for an extended period within tissue without circulating. Dogs with eCTCL often present with lesions in multiple locations, raising the question of whether the neoplasm is of the same T‐cell subpopulation or not.Objectives: To characterize the antigen receptor gene rearrangements of lymphocytes from skin and blood of dogs with eCTCL to determine if neoplastic clones are identical.Animals: Fourteen dogs with eCTCL.Materials and methods: Histological and immunohistochemical examination, and PCR for antigen receptor rearrangement (PARR) for T‐cell receptor gamma (TRG) performed on multiple cutaneous biopsy samples and blood.Results: All skin biopsies contained cluster of differentiation (CD)3‐positive neoplastic lymphocytes. Within individual dogs, all skin biopsies revealed identical TRG clonality profiles, suggesting that the same neoplastic clone was present in all sites. In the blood, a matching clone was found in six of 14 dogs, a unique clone was observed in nine of 14 dogs, and no clone was detected in two of 14 dogs.Conclusions: These findings show that canine eCTCL lesions in multiple locations harbour the same neoplastic clone, neoplastic lymphocytes do not remain fixed to the skin and instead can circulate via blood, differing clones can be identified in skin versus blood, and circulating neoplastic cells can be detected without lymphocytosis.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on Crossref: https://doi.org/10.1111/vde.13106