Peer-reviewed veterinary case report
Duodenal blood flow in dogs with chronic gut disease or lymphoma
By Nisa, Khoirun et al.·Published in Journal of veterinary internal medicine·2019·Department of Veterinary Clinical Sciences, Japan·View original on PubMed →
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Original publication title: Evaluation of duodenal perfusion by contrast-enhanced ultrasonography in dogs with chronic inflammatory enteropathy and intestinal lymphoma.
- Species:
- dog
Plain-English summary
A group of dogs with chronic gastrointestinal issues, including some with inflammatory bowel disease (CIE) and intestinal lymphoma, underwent a special ultrasound test to check blood flow in their intestines. The test showed that dogs with active symptoms of CIE had higher blood flow measurements compared to healthy dogs, suggesting that this method could help identify inflammation in the intestines. While the test was promising for diagnosing CIE, it didn't show significant differences between dogs with lymphoma and those with CIE or healthy dogs. This means that while the ultrasound can help with CIE, it may not be as useful for lymphoma cases.
People also search for: dog inflammatory bowel disease symptoms · dog ultrasound for intestinal issues · dog lymphoma diagnosis · chronic vomiting in dogs treatment
Abstract
BACKGROUND: Contrast-enhanced ultrasonography (CEUS) can be used to evaluate intestinal perfusion in healthy dogs. It is helpful for diagnosing and monitoring inflammatory bowel disease in humans and could be useful for dogs with chronic intestinal diseases. OBJECTIVES: To examine duodenal perfusion in dogs with chronic inflammatory enteropathy (CIE) and intestinal lymphoma. ANIMALS: Client-owned dogs with CIE (n = 26) or intestinal lymphoma (n = 7) and dogs with gastrointestinal signs but histopathologically normal duodenum (controls, n = 14). METHODS: In this cross-sectional study, dogs with CIE were classified into remission (n = 16) and symptomatic (n = 10) groups based on clinical scores determined at the time of CEUS. The duodenum was scanned after IV injection of Sonazoid® (0.01 mL/kg). CEUS-derived perfusion parameters, including time-to-peak, peak intensity (PI), area under the curve (AUC), and wash-in and wash-out rates were evaluated. RESULTS: The PI was significantly higher in the symptomatic CIE group (median (range); 105.4 (89.3-128.8) MPV) than in the control group (89.9 (68.5-112.2) MPV). The AUC was significantly higher in the symptomatic CIE group (4847.9 (3824.3-8462.8) MPV.sec) than in the control (3448.9 (1559.5-4736.9) MPV.sec) and remission CIE (3862.3 (2094.5-6899.0) MPV.sec) groups. The PI and clinical score were positively correlated in the CIE group. No significant differences in perfusion parameters were detected between the lymphoma and CIE groups or the lymphoma and control groups. CONCLUSIONS AND CLINICAL IMPORTANCE: The PI and AUC can detect duodenal inflammation and hence are potentially useful for excluding a diagnosis of CIE.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30784123/