Peer-reviewed veterinary case report
Topical treatments for cannon hyperkeratosis in horses
By Hilton, Hugo et al.·Published in Veterinary dermatology·2008·William R. Pritchard Veterinary Medical Teaching Hospital, United States·View original on PubMed →
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Original publication title: Evaluation of four topical preparations for the treatment of cannon hyperkeratosis in a horse.
- Species:
- horse
Plain-English summary
In this study, researchers looked at how well four different topical treatments worked for a specific skin condition called cannon hyperkeratosis in an 11-year-old Morgan horse mare. Over 30 days, the horse's legs were treated with either a tacrolimus ointment, adapalene gel, phytosphingosine spray, or a water-based moisturizer. The results showed that both the water-based moisturizer and the tacrolimus ointment led to noticeable improvements in the horse's skin condition. After treatment, tests showed a slight decrease in the thickness of the skin layers affected by the condition. Overall, the treatments were effective in helping reduce the severity of the hyperkeratosis.
Abstract
The response to treatment with four topical preparations was evaluated in an 11-year-old Morgan horse mare with histologically confirmed quadrilateral cannon hyperkeratosis. Each limb was treated for 30 days with 0.1% tacrolimus ointment, 0.1% adapalene gel, 0.2% phytosphingosine spray or a water-based emollient. Response to treatment was evaluated both histologically and visually. A water-based emollient and 0.1% tacrolimus ointment produced encouraging clinical responses. Pre-treatment histopathology identified marked, mostly compact, hyperkeratosis and follicular hyperkeratosis, most prominent in the infundibular area. Following treatment, histopathology identified a mild reduction in follicular keratin production and stratum corneum thickness.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19055613/