Peer-reviewed veterinary case report
Low cortisol after trilostane treatment in dogs with Cushing's disease
By Appleman, Elizabeth et al.·Published in Journal of the American Animal Hospital Association·2021·View original on PubMed →
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Original publication title: Evaluation of Iatrogenic Hypocortisolemia Following Trilostane Therapy in 48 Dogs with Pituitary-Dependent Hyperadrenocorticism.
- Species:
- dog
Plain-English summary
A group of 48 dogs with pituitary-dependent Cushing's disease were treated with a medication called trilostane, but some developed a condition called iatrogenic hypocortisolemia (iHC), which means their cortisol levels dropped too low. After six months, about 76% of these dogs had cortisol levels return to normal. At the end of the study, some dogs were still on medications to help their adrenal glands, while others were not on any adrenal-related treatments. Unfortunately, it was hard to predict how each dog would respond or recover after developing iHC.
People also search for: dog Cushing's disease treatment · trilostane side effects in dogs · low cortisol levels in dogs
Abstract
This study aimed to retrospectively describe the clinical progression following diagnosis of iatrogenic hypocortisolemia (iHC) in 48 dogs receiving trilostane for pituitary-dependent hyperadrenocorticism. Cortisol concentrations were ≥1.5 mg/dL within 6 mo following diagnosis of iHC in 76.3% of dogs (95% confidence interval [CI] 59.8-88.6%). At the time of study completion, 25% of dogs (95% CI 13.6-39.6%) were receiving either glucocorticoids or mineralocorticoids or both; 42% of dogs (95% CI 27.6-56.8%) were on no adrenal-related medications; and the remaining 33% of dogs (95% CI 20.4-48.4%) were receiving trilostane. No patient-, clinicopathologic-, or trilostane-associated factors were identified to influence adrenal recovery following diagnosis of iHC, and it remains difficult to predict the clinical progression in this population of dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34370857/