Peer-reviewed veterinary case report
Evaluation of Iatrogenic Hypocortisolemia Following Trilostane Therapy in 48 Dogs with Pituitary-Dependent Hyperadrenocorticism.
- Journal:
- Journal of the American Animal Hospital Association
- Year:
- 2021
- Authors:
- Appleman, Elizabeth et al.
- Species:
- dog
Plain-English summary
This study looked at 48 dogs that developed low cortisol levels (called iatrogenic hypocortisolemia) after being treated with a medication called trilostane for a condition known as pituitary-dependent hyperadrenocorticism, which is a type of hormone imbalance. Most of the dogs, about 76%, had their cortisol levels return to normal within six months. At the end of the study, a quarter of the dogs were still on medications to help their adrenal glands, while 42% were not taking any adrenal-related medications, and the rest were still on trilostane. The researchers found that there were no specific factors that could help predict how well the dogs would recover after developing low cortisol levels. Overall, the treatment's effectiveness varied, and it was challenging to determine how each dog would progress.
Abstract
This study aimed to retrospectively describe the clinical progression following diagnosis of iatrogenic hypocortisolemia (iHC) in 48 dogs receiving trilostane for pituitary-dependent hyperadrenocorticism. Cortisol concentrations were ≥1.5 mg/dL within 6 mo following diagnosis of iHC in 76.3% of dogs (95% confidence interval [CI] 59.8-88.6%). At the time of study completion, 25% of dogs (95% CI 13.6-39.6%) were receiving either glucocorticoids or mineralocorticoids or both; 42% of dogs (95% CI 27.6-56.8%) were on no adrenal-related medications; and the remaining 33% of dogs (95% CI 20.4-48.4%) were receiving trilostane. No patient-, clinicopathologic-, or trilostane-associated factors were identified to influence adrenal recovery following diagnosis of iHC, and it remains difficult to predict the clinical progression in this population of dogs.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/34370857/