Peer-reviewed veterinary case report
Ifosfamide treatment results and side effects in dogs with metastatic
By Batschinski, K. et al.·Published in Veterinary and Comparative Oncology·2012·Veterinary Medical Center, Center for Comparative Oncology Michigan State University East Lansing MI USA, United States·View original on Crossref →
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Original publication title: Evaluation of ifosfamide salvage therapy for metastatic canine osteosarcoma
- Species:
- dog
Plain-English summary
Nineteen dogs with metastatic osteosarcoma (a type of bone cancer) that had already undergone standard chemotherapy were treated with ifosfamide, a chemotherapy drug, to see if it could help them. Out of the 17 dogs that were monitored, only two showed any improvement, with one dog having a complete response and another a partial response. Unfortunately, most dogs did not respond well, and 13 experienced disease progression. While some dogs had to be hospitalized due to side effects, ifosfamide was generally tolerated. The average survival time after starting ifosfamide was about 95 days.
People also search for: dog osteosarcoma treatment · ifosfamide for dogs · metastatic bone cancer in dogs
Abstract
AbstractA retrospective study was performed to assess toxicity and response rate of ifosfamide salvage treatment for dogs diagnosed with metastatic osteosarcoma (OSA). Dogs diagnosed withOSAand previously treated with standard chemotherapy were included in the study. Nineteen dogs met the inclusion criteria, and 17 dogs were evaluable for response. Ifosfamide doses ranged from 375 to 425 mg m−2(median dose 375 mg m−2), with a median of two doses administered per dog (range 1–7 doses). The overall response to ifosfamide was 11.8% [complete response (CR) = 1/17, partial response (PR) = 1/17,stable disease (SD) = 2/17, progressive disease (PD) = 13/17]. Two dogs were hospitalized due to ifosfamide toxicosis. The median survival duration from the first dose of ifosfamide to death was 95 days. Ifosfamide was well tolerated, but minor anti‐tumour activity was observed.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/j.1476-5829.2012.00355.x