Peer-reviewed veterinary case report
Ifosfamide chemo shows limited response in dogs with metastatic bone
By Batschinski, K et al.·Published in Veterinary and comparative oncology·2014·Michigan State University, United States·View original on PubMed →
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Original publication title: Evaluation of ifosfamide salvage therapy for metastatic canine osteosarcoma.
- Species:
- dog
Plain-English summary
Nineteen dogs with metastatic osteosarcoma (bone cancer) that had already undergone standard chemotherapy were treated with ifosfamide, a type of chemotherapy, to see if it could help them. Of the 17 dogs that could be evaluated, only two showed any improvement, with one dog having a complete response and another a partial response. Unfortunately, most dogs did not improve, and some experienced side effects that required hospitalization. On average, the dogs lived about 95 days after starting ifosfamide treatment. While it was generally tolerated, the treatment showed limited effectiveness in fighting the cancer.
People also search for: dog osteosarcoma treatment · ifosfamide for dogs · metastatic bone cancer in dogs · dog cancer survival rate · side effects of ifosfamide in dogs
Abstract
A retrospective study was performed to assess toxicity and response rate of ifosfamide salvage treatment for dogs diagnosed with metastatic osteosarcoma (OSA). Dogs diagnosed with OSA and previously treated with standard chemotherapy were included in the study. Nineteen dogs met the inclusion criteria, and 17 dogs were evaluable for response. Ifosfamide doses ranged from 375 to 425 mg m(-2) (median dose 375 mg m(-2)), with a median of two doses administered per dog (range 1-7 doses). The overall response to ifosfamide was 11.8% [complete response (CR) = 1/17, partial response (PR) = 1/17, stable disease (SD) = 2/17, progressive disease (PD) = 13/17]. Two dogs were hospitalized due to ifosfamide toxicosis. The median survival duration from the first dose of ifosfamide to death was 95 days. Ifosfamide was well tolerated, but minor anti-tumour activity was observed.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22985083/