Peer-reviewed veterinary case report
Gene differences linked to sulfonamide allergy in dogs
By Funk-Keenan, J et al.·Published in Journal of veterinary internal medicine·2012·Department of Medical Sciences, United States·View original on PubMed →
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Original publication title: Evaluation of polymorphisms in the sulfonamide detoxification genes CYB5A and CYB5R3 in dogs with sulfonamide hypersensitivity.
- Species:
- dog
Plain-English summary
A group of dogs with delayed allergic reactions to a type of antibiotic called sulfonamides was studied to see if certain genetic differences made them more likely to have these reactions. Researchers found that a specific genetic variant (729GG) was much more common in dogs that had hypersensitivity compared to those that tolerated the medication without issues. This suggests that the 729GG variant in the CYB5R3 gene may increase the risk of allergic reactions to sulfonamides in dogs. Further research is needed to understand this genetic link better.
People also search for: dog sulfonamide allergy symptoms · dog antibiotic hypersensitivity · genetic testing for dog allergies
Abstract
BACKGROUND: Delayed hypersensitivity (HS) reactions to potentiated sulfonamide antimicrobials occur in both dogs and humans, and involve an intermediate hydroxylamine metabolite that is detoxified by cytochrome b(5) and NADH cytochrome b(5) reductase. HYPOTHESIS/OBJECTIVES: We hypothesized that polymorphisms in the genes (CYB5A and CYB5R3) encoding these 2 enzymes would be associated with risk of sulfonamide HS in dogs. ANIMALS: A total of 18 dogs with delayed HS to potentiated sulfonamide antimicrobials and 16 dogs that tolerated (TOL) a therapeutic course of these drugs without adverse effect. METHODS: CYB5A and CYB5R3 were sequenced from canine liver, and the promoter, exons, and 3' untranslated regions of both genes were resequenced from genomic DNA obtained from all dogs. RESULTS: Multiple polymorphisms were found in both genes. When controlled for multiple comparisons, the 729GG variant in CYB5R3 was significantly overrepresented in dogs with sulfonamide HS (78% of dogs), compared to TOL dogs (31%; P = .003). CONCLUSIONS AND CLINICAL IMPORTANCE: The CYB5R3 729GG variant may contribute to the risk of sulfonamide HS in dogs. Functional characterization of this polymorphism, as well as genotyping in a larger number of HS and TOL dogs, is warranted.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22816446/