Peer-reviewed veterinary case report
Blood and stool test results in cats with low-grade intestinal
By Gavazza, Alessandra et al.·Published in Research in veterinary science·2025·School of Biosciences and Veterinary Medicine, Italy·View original on PubMed →
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Original publication title: Evaluation of serum and fecal parameters in cats with low-grade intestinal T-cell lymphoma (LGITCL).
- Species:
- cat
Plain-English summary
A group of 12 cats with low-grade intestinal T-cell lymphoma (LGITCL) showed changes in their gut bacteria and blood markers compared to 12 healthy cats. The cats with lymphoma had lower levels of certain beneficial bacteria and higher levels of harmful bacteria. Blood tests revealed lower total protein, amylase, and cholesterol levels in the affected cats, suggesting they might be losing protein through their intestines. These findings indicate that LGITCL may disrupt the normal gut environment and lead to gastrointestinal issues. Further research is needed to confirm these results and explore additional changes.
People also search for: cat intestinal lymphoma symptoms · cat low protein diet · cat gut bacteria changes
Abstract
Lymphoma is the most common neoplasia in the intestine of cats. According to ACVIM consensus statement, low-grade intestinal T-cell lymphoma (LGITCL) represents a monomorphic infiltration of the lamina propria or epithelium or both of cats with small, mature, neoplastic (clonal) T lymphocytes. Despite the importance as contributing factors of inheritance and environment in the pathogenesis of LGITCL, the chronic inflammatory status plays a fundamental role. The aim of the present study was to investigate possible diagnostic and prognostic parameters in LGITCL. Selected fecal bacteria and serum biomarkers (serum amyloid A [SAA]; citrulline; total protein; amylase; lipase; DGGR lipase; cholesterol; lipopolysaccharides [LPS], and zonulin) were evaluated in 12 cats (lymphoma group - LG) with histologically diagnosed low-grade intestinal T- cell lymphoma (LGITCL) and then compared with a control group consisting of 12 clinically healthy cats (CG). The evaluation of fecal bacterial population showed the significant decrease of Faecalibacterium spp. (P = 0,045) and Clostridium hiranonis (P = 0,0433) and a significant increase in E. coli (P = 0,045), Streptococcus spp. (P = 0,0003) and Turicibacter spp. (P = 0,0056) in the lymphoma group. Serology showed a significant decrease of total proteins (P = 0,092), amylase (P = 0,092) and cholesterol (P = 0,0112) in LG group compared to controls. The present results allowed the authors to state that in cats LGITCL is possibly associated to a change in the gastrointestinal environment and to a condition of protein losing enteropathy. Further studies with a larger cohort of patients are needed to confirm the present results and to point out other possible changes.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39753058/