Peer-reviewed veterinary case report
Serum cystatin-C levels in dogs with visceral leishmaniasis
By Pasa, S et al.·Published in Veterinary research communications·2009·Department of Internal Medicine·View original on PubMed →
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Original publication title: Evaluation of serum cystatin-C in dogs with visceral leishmaniasis.
- Species:
- dog
Plain-English summary
A group of 16 dogs with visceral leishmaniasis (a serious infection) showed higher levels of a kidney function marker called serum cystatin C compared to 10 healthy dogs. This suggests that the infected dogs may have some kidney issues. While other kidney-related tests showed changes, they weren't significant enough to draw firm conclusions. More research is needed to fully understand the impact of visceral leishmaniasis on kidney health in dogs. If your dog has been diagnosed with this infection, it's important to monitor their kidney function closely.
People also search for: dog kidney problems leishmaniasis · high cystatin C in dogs · kidney function tests for dogs
Abstract
Serum Cystatin C (sCys-C) is one of the most important serum markers of renal function assessment in dogs. The purpose of this study was to determine the sCys-C concentration in dogs with visceral leishmaniasis (VL). In the study, 16 dogs with VL and 10 clinical healty dogs (control) were used. Mean sCys-C concentration of the infected dogs was significantly higher than that of the control group (p < 0.05). Mean serum creatinine concentration was lower and mean blood urea nitrogen, albumin and globulin concentrations were higher in dogs with VL; however, these changes were not statistically significant. Mean total protein and phosphorus concentrations were found to be higher in dogs with VL than healthy dogs (p < 0.05). No significant correlation had been determined between sCys-C and other variables. Visceral leishmaniasis in dogs has increased sCys-C concentration indicating a possible renal impairment; however, further studies are needed to be performed together with renal biopsies in the investigation sCys-C in dogs with VL.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19140021/