Peer-reviewed veterinary case report
Urine C reactive protein levels in dogs with leishmaniasis and kidney
By Martínez-Subiela, Silvia et al.·Published in Research in veterinary science·2013·Animal Medicine and Surgery Department, Spain·View original on PubMed →
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Original publication title: Urinary C reactive protein levels in dogs with leishmaniasis at different stages of renal damage.
- Species:
- dog
Plain-English summary
A group of dogs with leishmaniasis (a disease caused by a parasite) showed increased levels of a protein called C reactive protein (CRP) in their urine, especially those with kidney damage. The study found that dogs with both protein in their urine and high serum creatinine levels (which indicate kidney issues) had the highest CRP levels. This suggests that measuring CRP in urine could help veterinarians assess kidney damage in dogs suffering from leishmaniasis.
People also search for: dog leishmaniasis symptoms · dog kidney damage treatment · elevated CRP in dogs
Abstract
The objectives of the study were to validate a time-resolved immunofluorometric assay for C reactive protein (CRP) quantification in urine of dogs and to investigate the influence that the presence of proteinuria and azotemia could have on serum and urinary CRP (uCRP) values in dogs with leishmaniasis. Samples obtained from dogs naturally infected with Leishmania infantum were classified into four groups on the basis of the results of urinary protein/creatinine ratio and serum creatinine (sCr). In addition, 7 dogs were monitored at initial diagnosis and after a follow up visit. The assay showed good analytical performance based on precision, accuracy and limit of detection results. Results of the study suggested that CRP is present in urine of dogs with leishmaniasis and renal damage since uCRP/creatinine ratio was significantly increased in dogs with proteinuria, being the highest values observed in dogs with proteinuria and elevated sCr, and that the measurement of uCRP could be a tool to detect and evaluate the possible kidney damage associated with this disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23932765/