Peer-reviewed veterinary case report
Blood levels of FGF23 and magnesium in dogs and cats with sudden
By Miyagawa, Akiko et al.·Published in Veterinary journal (London, England : 1997)·2025·Nippon Veterinary and Life Science University, Japan·View original on PubMed →
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Original publication title: Evaluation of serum FGF23 and serum magnesium levels in dogs and cats with acute kidney injury.
- Species:
- dog
Plain-English summary
A group of dogs and cats with acute kidney injury (AKI) had higher levels of a protein called FGF-23 and increased magnesium in their blood compared to healthy pets. This study found that dogs with AKI had FGF-23 levels over seven times higher than normal and elevated magnesium levels as well. In cats, FGF-23 levels were also significantly higher in those with AKI. These findings suggest that monitoring FGF-23 and magnesium could be important for understanding kidney health in pets with AKI.
People also search for: dog acute kidney injury symptoms · cat kidney disease treatment · high magnesium in dogs · FGF-23 in pets · kidney injury in cats
Abstract
Acute kidney injury (AKI) is caused by sudden kidney damage. In studies using mouse model of AKI, the blood concentrations of fibroblast growth factor-23 (FGF-23) increased persistently in AKI. In addition, higher FGF-23 concentrations were associated with the progression of AKI to chronic kidney disease (CKD), and AKI disrupted magnesium homeostasis. However, no study has evaluated these factors in dogs and cats with AKI. This study aimed to measure serum FGF-23 and magnesium concentrations in dogs and cats with AKI. This cross-sectional study used data available in medical records. The AKI group included six dogs and six cats, while the control group consisted of eight dogs and six cats, all of which were client-owned animals. Results showed that in dogs, the AKI group had significantly higher serum FGF-23 (median control, 278.5 pg/mL; AKI, 2104.0 pg/mL; P = 0.02), and magnesium (median control, 2.0 mg/dL; AKI, 2.65 mg/dL; P = 0.043) concentrations than the control group. In cats, the AKI group had significantly higher FGF-23 (median control, 138 pg/mL; AKI, 1195 pg/mL; P = 0.015) concentrations than the control group. In addition, serum FGF-23 concentrations were a significant positive correlation with serum creatinine (r = 0.67, P = 0.018) and phosphate concentrations (r = 0.893, P < 0.001) in dogs.To the best of knowledge, the current study first reported that dogs and cats with AKI had increased serum FGF-23 concentrations. Moreover, dogs with AKI exhibited high serum magnesium concentrations.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41265695/