Peer-reviewed veterinary case report
Serum HMGB1 levels are higher in dogs with epilepsy
By Koo, Yoonhoi et al.·Published in Journal of veterinary internal medicine·2020·College of Veterinary Medicine, South Korea·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Evaluation of serum high-mobility group box 1 concentration in dogs with epilepsy: A case-control study.
- Species:
- dog
Plain-English summary
A group of 28 dogs with epilepsy had higher levels of a protein called HMGB1 in their blood compared to healthy dogs, suggesting it could be a marker for the condition. The study found that dogs with epilepsy for more than three months had even higher levels of HMGB1 than those diagnosed more recently. This means that measuring HMGB1 might help veterinarians understand and diagnose epilepsy in dogs better. While this research is still in the early stages, it could lead to improved monitoring and treatment options for dogs suffering from seizures.
People also search for: dog epilepsy symptoms · high HMGB1 levels in dogs · dog seizure treatment options
Abstract
BACKGROUND: High-mobility group box 1 (HMGB1) is a key mediator of neuroinflammation and there are increased HMGB1 levels in laboratory animal models of epilepsy and human patients with epilepsy. OBJECTIVES: To determine serum HMGB1 levels in dogs with epilepsy. ANIMALS: Twenty-eight epileptic dogs, 12 dogs with nonepileptic brain diseases, and 26 healthy dogs. METHODS: In this case-control study, serum HMGB1 concentrations were estimated using the canine-specific enzyme-linked immunosorbent assay kit. Diagnosis of dogs with epilepsy was based on medical history, physical and neurological examination findings, laboratory test results, magnetic resonance image, and cerebrospinal fluid analysis. RESULTS: Serum HMGB1 levels were significantly higher in epileptic dogs (median = 0.41 ng/mL; range, 0.03-5.28) than in healthy dogs (median = 0.12 ng/mL; range, 0.02-1.45; P = .002). In contrast, serum HMGB1 levels of dogs with non-epileptic brain diseases (median = 0.19 ng/mL; range, 0.03-1.04) were not significantly increased compared to those of healthy dogs (P = .12). Regarding idiopathic epilepsy, dogs with an epilepsy course of >3 months showed a higher serum HMGB1 concentration (median = 0.87 ng/mL; range, 0.42-2.88) than those with that of ≤3 months (median = 0.26 ng/mL; range, 0.03-0.88; P = .02). CONCLUSIONS AND CLINICAL IMPORTANCE: Serum HMGB1 could be a biomarker of epilepsy.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33150666/