Peer-reviewed veterinary case report
Heart safety of meglumine antimoniate in dogs with leishmaniasis
By Luciani, Alessia et al.·Published in Veterinary journal (London, England : 1997)·2013·Department of Veterinary Clinical Sciences, Italy·View original on PubMed →
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Original publication title: Evaluation of the cardiac toxicity of N-methyl-glucamine antimoniate in dogs with naturally occurring leishmaniasis.
- Species:
- dog
Plain-English summary
A group of 28 dogs with leishmaniasis (a disease caused by a parasite) were treated with a medication called meglumine antimoniate for 60 days to see if it caused any heart problems. The dogs were monitored for heart health before and after treatment using blood tests and heart rhythm checks. Fortunately, there were no signs of heart damage or abnormal heart rhythms in any of the dogs during or after the treatment. This suggests that the medication is safe for the heart when given at the recommended dose.
People also search for: dog leishmaniasis treatment · meglumine antimoniate side effects · dog heart problems treatment
Abstract
The aim of this study was to evaluate the cardiotoxic effects of pentavalent antimonial compounds in dogs with leishmaniasis. Twenty-eight dogs with clinical disease due to natural infection with Leishmania infantum were treated with 75 mg/kg meglumine antimoniate SC every 12h for 60 days. Serum cardiac troponin I (cTnI) concentrations were determined and routine and 24h ambulatory electrocardiographic monitoring was performed before the onset (T0) and at the end of treatment (T60). No abnormalities were found in routine and 24h electrocardiographic tracings before and after treatment. No statistical difference was found between serum cTnI concentrations or corrected QT intervals at T0 and T60. There was no evidence of laboratory or electrocardiographic features of cardiac toxicity in dogs with leishmaniasis treated with a therapeutic dose of meglumine antimoniate for 60 days.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23021954/