Evaluation of the Clinical Efficacy of Copine 7-Derived Peptides for Naturally Occurring Periodontitis in Dogs.

Abstract

AIM: To assess the efficacy of copine7-derived peptide (CPNE7-DP) applied in conjunction with non-surgical dental treatments in improving naturally occurring periodontitis in dogs. MATERIALS AND METHODS: This study included 24 client-owned dogs with mild to moderate periodontitis, randomly assigned to three groups: CPNE7-DP; a placebo control group receiving carrier material; and a negative control group left untreated. Experimental agents were applied after professional dental cleaning. Clinical assessments were conducted at Weeks 0, 4 and 8, which involved measurements of gingival index (GI), periodontal pocket depth (PPD), clinical attachment loss (CAL) and bleeding on probing (BoP). Alveolar bone loss (ABL) was evaluated using intraoral radiographs. RESULTS: Application of CPNE7-DP resulted in a significant improvement in GI, PPD, CAL and BoP compared with both placebo and negative control groups. ABL was significantly reduced in the CPNE7-DP group. These clinical outcomes indicated the potential regenerative effects of CPNE7-DP on periodontal tissues. CONCLUSIONS: Topical application of CPNE7-DP in conjunction with non-surgical dental treatments was effective in reducing gingival inflammation, PPD, CAL and ABL in dogs with naturally occurring periodontitis. These findings suggest the potential of CPNE7-DP as an effective adjunctive therapeutic agent for periodontal treatment. TRIAL REGISTRATION: Approved by the Institutional Animal Care and Use Committee of Seoul National University (SNU-220520-5-1).