Evaluation of the effects of a single bolus of cisatracurium as part of an anesthetic protocol in cats undergoing orthopedic surgery.

Abstract

Non-depolarizing neuromuscular blocking agents (NMBAs) are commonly used in human anesthesia but remain uncommon in veterinary medicine. This study evaluated the effects of 0.5&#xa0;mg/kg cisatracurium IV on muscle relaxation, cardiovascular variables and postoperative pain in cats undergoing orthopedic surgery. Twenty-four cats were randomly assigned to a control group (Group C) or a treatment group receiving cisatracurium (Group M) immediately after induction. Neuromuscular function was monitored using a calibrated train-of-four (TOF) device. Postoperative pain was assessed with the short form of the Glasgow Feline Composite Measure Pain Scale (CMPS-Feline). The mean time to suppression of muscle contraction was 2.6&#x2009;&#xb1;&#x2009;0.8&#xa0;min, with peak suppression (90%) at 3.0&#x2009;&#xb1;&#x2009;0.7&#xa0;min, a mean duration of 23.3&#x2009;&#xb1;&#x2009;4.4&#xa0;min, and complete recovery at 27.3&#x2009;&#xb1;&#x2009;8.6&#xa0;min. Group M required lower sevoflurane concentrations to maintain anesthesia compared to Group C (p&#x2009;<&#x2009;0.001) and had a shorter mean surgical time (25.3&#x2009;&#xb1;&#x2009;3&#xa0;min vs. 31.5&#x2009;&#xb1;&#x2009;4&#xa0;min; p&#x2009;<&#x2009;0.001). Pain scores were also lower in Group M (p&#x2009;=&#x2009;0.01). These findings demonstrate that cisatracurium effectively induces neuromuscular block (NMB) and improves surgical conditions, resulting in lower postoperative pain scores in cats undergoing femoral fracture repair.