Peer-reviewed veterinary case report
Topical emodepside plus praziquantel kills cat roundworm infections
By Reinemeyer, C R et al.·Published in Parasitology research·2005·East Tennessee Clinical Research, United States·View original on PubMed →
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Original publication title: Evaluation of the efficacy of emodepside plus praziquantel topical solution against ascarid infections (Toxocara cati or Toxascaris leonina) in cats.
- Species:
- cat
Plain-English summary
A group of cats with ascarid infections (a type of roundworm) were treated with a topical solution containing emodepside and praziquantel to see how well it worked. The treatment was found to be 100% effective against adult and immature adult Toxocara cati, and it also showed very high effectiveness against various larval stages of the parasite. No side effects were reported in the cats that received the treatment. This means that the topical solution is a safe and effective option for treating these types of worm infections in cats.
People also search for: cat roundworm treatment · emodepside praziquantel for cats · how to treat Toxocara cati in cats
Abstract
Eleven controlled studies were conducted in the United States and Europe to evaluate the efficacy of a topical solution of emodepside (3 mg/kg)+praziquantel (12 mg/kg) (Profender, Bayer AG, Leverkusen, Germany) against infection with various stages of the ascarid nematodes Toxocara cati and Toxascaris leonina. Infections were induced by administration of larvated ascarid eggs, and stage-specific efficacy was evaluated by treating cats at scheduled intervals post-inoculation. All studies featured random allocation to treatment groups, placebo-treated control animals and assessment of outcome measures by masked personnel. The product (emodepside+praziquantel topical solution) was 100% effective against mature adults and immature adult T. cati. In addition, it was 96.8% effective against third stage larvae and at least 99.4% effective against fourth stage larvae of T. cati, respectively. Efficacy against mature, immature adult and L4 stages of T. leonina exceeded 93.4%, but regulatory "adequacy of infection" criteria were not met in some studies. No adverse reactions to treatment were noted in cats treated with the emodepside+praziquantel topical solution.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16228274/