Peer-reviewed veterinary case report
Modified Glasgow Prognostic Score predicts survival in dogs
By Fontaine, S J et al.·Published in Veterinary and comparative oncology·2017·School of Veterinary Medicine, United Kingdom·View original on PubMed →
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Original publication title: Evaluation of the modified Glasgow Prognostic Score to predict outcome in dogs with newly diagnosed lymphoma.
- Species:
- dog
Plain-English summary
A study looked at 77 dogs with newly diagnosed lymphoma to see if a scoring system could help predict how well they would do with treatment. The modified Glasgow Prognostic Score (mGPS) used blood tests to measure levels of certain proteins, which were linked to symptoms like weight loss, lethargy, and gastrointestinal issues. Dogs with a higher mGPS score had shorter survival times. While the score showed promise in predicting outcomes, more research is needed to confirm its effectiveness.
People also search for: dog lymphoma prognosis · canine lymphoma treatment options · signs of lymphoma in dogs
Abstract
The modified Glasgow Prognostic Score (mGPS) assigns a numerical value (0-2) from pre-treatment serum concentrations of C-reactive protein (CRP) and albumin to predict patient outcome. CRP and albumin were evaluated in 77 untreated dogs with lymphoma to determine the relationship of mGPS to clinicopathological parameters and whether it could predict progression-free (PFS) and overall survival (OS) in treated dogs. mGPS distribution was significantly associated with clinical stage, substage b, weight loss, gastrointestinal disturbances and lethargy at presentation. On univariate analysis, mGPS was significantly associated with OS and PFS, with shorter median survival times for mGPS 2 compared to mGPS 0 and 1 combined. Hypoalbuminaemia significantly reduced OS and PFS, however increased CRP had no effect. Only clinical stage was significantly associated with OS and PFS on both univariate and multivariate analysis. mGPS has potential prognostic value for canine lymphoma , but further studies are needed.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28150446/