Peer-reviewed veterinary case report
Progression of proteinuric kidney disease in dogs without azotemia
By Miyakawa, H et al.·Published in Research in veterinary science·2021·Nippon Veterinary and Life Science University, Japan·View original on PubMed →
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Original publication title: Evaluation of the progression of non-azotemic proteinuric chronic kidney disease in dogs.
- Species:
- dog
Plain-English summary
A group of 21 dogs with chronic kidney disease (CKD) that wasn't causing high levels of waste in the blood (non-azotemic) were studied to understand how protein in their urine affected their condition. The researchers found that higher levels of proteinuria (protein in urine) and albuminuria (albumin in urine) were linked to faster disease progression. They determined that if the urine protein-to-creatinine ratio (UPC) was 4.1 or higher, and the urine albumin-to-creatinine ratio (UAC) was 2.0 or higher, these dogs were likely to worsen more quickly. This suggests that treatment should be considered for dogs showing these signs to help slow down the progression of CKD.
People also search for: dog kidney disease symptoms · protein in dog urine treatment · chronic kidney disease in dogs management
Abstract
Proteinuria is a recognized risk factor for progression of canine chronic kidney disease (CKD). However, the prognosis of non-azotemic proteinuric CKD in dogs has been studied only to a limited extent. Moreover, the degree to which proteinuria should be decreased to delay CKD progression remains unknown. The purposes of this study were (1) to identify factors associated with disease progression and (2) to investigate the degree of proteinuria, albuminuria, and blood pressure during the course of treatment associated with the progression using time-averaged urine protein:creatinine ratio (UPC) and urine albumin:creatinine ratio (UAC) in canine non-azotemic proteinuric CKD. Twenty-one dogs with non-azotemic proteinuric CKD were included in the study. High UPC and UAC were associated with CKD progression (P < .05). Time-averaged high UPC and UAC were significantly related to progression (P < .05). The cutoff values of these time-averaged parameters for predicting the progression were 4.1 and 2.0, respectively. In dogs with non-azotemic proteinuric CKD, more severe proteinuria and albuminuria were associated with progression. The present study suggests that because UPC ≥ 4.1 and UAC ≥ 2.0 during treatment were associated with a faster progression of non-azotemic proteinuric CKD, therapeutic intervention is warranted.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34090202/