Peer-reviewed veterinary case report
LOPP chemotherapy for relapsed lymphoma in 33 dogs 2003-2009
By Fahey, Christine E et al.·Published in Journal of the American Veterinary Medical Association·2011·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Evaluation of the University of Florida lomustine, vincristine, procarbazine, and prednisone chemotherapy protocol for the treatment of relapsed lymphoma in dogs: 33 cases (2003-2009).
- Species:
- dog
Plain-English summary
A group of 33 dogs with lymphoma that didn't respond to initial chemotherapy treatments were given a new combination of drugs called the University of Florida LOPP protocol, which includes lomustine, vincristine, procarbazine, and prednisone. About 61% of the dogs showed improvement, with 36% achieving complete remission and 24% showing partial improvement. The dogs were monitored for an average of 290 days after starting the treatment, and the side effects were less severe compared to previous treatments. This protocol could be a good option for dogs with relapsed lymphoma.
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Abstract
OBJECTIVE: To evaluate the toxicity and efficacy of a modification of a previously evaluated combination of lomustine, vincristine, procarbazine, and prednisone (LOPP) as a rescue protocol for refractory lymphoma in dogs. DESIGN: Retrospective case series. Animals-33 dogs with a cytologic or histologic diagnosis of lymphoma that developed resistance to their induction chemotherapy protocol. PROCEDURES: Lomustine was administered on day 0 of the protocol. Vincristine was administered on day 0 and again 1 time on day 14. Procarbazine and prednisone were administered on days 0 through 13 of the protocol. This cycle was repeated every 28 days. RESULTS: Median time from initiation to discontinuation of the University of Florida LOPP protocol was 84 days (range, 10 to 308 days). Overall median survival time was 290 days (range, 51 to 762 days). Overall response rate with this protocol was 61% (20/33), with 36% (12) having a complete response and 24% (8) having a partial response. Toxicosis rates were lower than for the previously published LOPP protocol. CONCLUSIONS AND CLINICAL RELEVANCE: The University of Florida LOPP protocol may be an acceptable alternative to the mechlorethamine, vincristine, procarbazine, and prednisone protocol as a rescue protocol for dogs with lymphoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21756176/