Peer-reviewed veterinary case report
Urine and blood tests for early kidney injury in hospitalized dogs
By Perondi, Francesca et al.·Published in The Veterinary record·2019·Dipartimento di Scienze Veterinarie, Italy·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Evaluation of urinary γ-glutamyl transferase and serum creatinine in non-azotaemic hospitalised dogs.
- Species:
- dog
Plain-English summary
A group of 97 hospitalized dogs were tested for signs of acute kidney injury (AKI) after showing symptoms like decreased urine production. The study found that many of these dogs had early signs of kidney issues, with 64% classified as having mild AKI. A specific urine test measuring a protein called uGGT was effective in identifying these dogs, helping vets determine which ones were at higher risk of complications. Unfortunately, some of the dogs with increased kidney markers had a higher chance of dying during their hospital stay. The findings suggest that uGGT can be a useful tool for vets in diagnosing early kidney problems in dogs.
People also search for: dog kidney injury symptoms · acute kidney injury in dogs · uGGT test for dogs
Abstract
Urinary and blood biomarkers for diagnosis of acute kidney injury (AKI) in hospitalised dogs were evalueted. This prospective study included 97 dogs, classified according to the International Renal Interest Society classification into no AKI and AKI grade 1 (48-hour increase in serum creatinine≥0.3 mg/dl and/or urinary production <1 ml/kg/hour for at least six hours). A total of 62 of 97 dogs (64 per cent) were classified as AKI 1. A statistically significant difference was found between no AKI and AKI 1 in urine protein to creatinine ratio, urinary γ-glutamyl transferase (uGGT) and uGGT/cu (P<0.0001). Thirteen of 97 dogs (13.4 per cent) that developed increased creatinine and change in AKI grade showed high mortality (n=9/13; 69.2 per cent). The receiver operating characteristic (ROC) curve analysis of uGGT/cu index as a marker for AKI grade 1 had an area under the ROC curve of 0.78; optimal cut-off point was 57.50 u/g, with sensitivity and specificity of 75.4 per cent and 75.6 per cent, respectively. Overall intensive care unit mortality was 23.7 per cent (23/97), 13.4 per cent (13/97) of which died during hospitalisation and 10.3 per cent (10/97) within 28 days after discharge. uGGT is an acceptable marker for distinguishing between AKI 1 and no AKI.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31076519/