Peer-reviewed veterinary case report
Eyelid melanocytoma with blood-filled spaces in a Doberman dog
By Nordio, L et al.·Published in Journal of comparative pathology·2018·Department of Veterinary Medicine, Italy·View original on PubMed →
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Original publication title: Evidence of Vasculogenic Mimicry in a Palpebral Melanocytoma in a Dog.
- Species:
- dog
Plain-English summary
A 7-year-old female Doberman was brought to the vet because of a growth on her left eyelid. The vet surgically removed the nodule, which turned out to be a type of skin tumor called a melanocytoma. This tumor had some unusual features that are typically seen in human tumors, indicating a unique way it was growing. Thankfully, the surgery was successful, and the dog is expected to recover well.
People also search for: dog eyelid growth · Doberman eyelid tumor treatment · melanocytoma in dogs
Abstract
A 7-year-old neutered female Doberman pinscher was presented with a palpebral nodule on the haired eyelid of the left eye. The nodule was removed surgically. Microscopically, the nodule was consistent with eyelid melanocytoma. The tumour was characterized by the presence of numerous lacunar and slit-like spaces filled by erythrocytes and interspersed throughout the neoplastic melanocytes. Immunohistochemically, these spaces were lined by cells expressing PNL2, but the cells were negative for factor VIII and CD31. [corrected] These findings were consistent with neoplastic melanocytes without endothelial cell participation. This feature was interpreted as 'vasculogenic mimicry', a mechanism of tumour angiogenesis that is well-recognized in human melanomas, but has not yet been reported in melanomas in animals.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30060841/