Peer-reviewed veterinary case report
Feline oral cancer survival linked to low Ki67 levels
By Bergkvist, G T et al.·Published in Veterinary and comparative oncology·2011·Royal (Dick) School of Veterinary Studies and Roslin Institute, United Kingdom·View original on PubMed →
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Original publication title: Expression of epidermal growth factor receptor (EGFR) and Ki67 in feline oral squamous cell carcinomas (FOSCC).
- Species:
- cat
Plain-English summary
A study looked at 67 biopsy samples from cats with oral squamous cell carcinoma, a type of mouth cancer. The researchers found that all samples showed certain proteins (EGFR and Ki67) that might help predict how long a cat could survive after diagnosis. On average, cats lived about 46 days after their diagnosis, with only 5% surviving a year. Interestingly, cats with lower levels of the Ki67 protein tended to live longer. This suggests that testing for these proteins could help veterinarians assess the severity of the cancer and guide treatment options.
People also search for: cat mouth cancer survival rate · feline oral squamous cell carcinoma treatment · cat cancer biopsy results
Abstract
The aims of this study were to establish expression of epidermal growth factor receptor (EGFR) and Ki67 in 67 archived biopsy samples of feline oral squamous cell carcinomas (FOSCCs) and to establish if the expression of either markers was predictive of survival. Samples were immunohistochemically labelled for the two proteins and scored. Statistical analyses of data, including Kaplan-Meier survival curves, were performed. All samples expressed both markers although levels differed between samples. Median overall survival was 46 days and 1-year survival was 5%. There was no correlation between Ki67 and EGFR scores (Pearson's correlation coefficient, P = 0.861). Low cellular proliferation (low Ki67 score) was positively correlated with an overall longer survival (Log Rank, P = 0.02) and a trend towards better survival for the high EGFR group was observed (Log Rank, P = 0.076). Ki67 and EGFR immunostaining in FOSCC may be of value as biochemical markers for screening of biopsies from cases of FOSCC.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21569196/