Peer-reviewed veterinary case report
Muscle immune response in a puppy dog with Neospora myositis
By Paciello, O et al.·Published in Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology·2004·Dipartimento di Patologia e Sanità, Italy·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Expression of Major Histocompatibility Complex class I and II in a case of Neospora caninum myositis in a dog.
- Species:
- dog
Plain-English summary
A 2-month-old puppy was diagnosed with Neospora caninum infection, which caused muscle inflammation (myositis). The diagnosis was confirmed through specific blood tests and tissue examination. The puppy's immune system was activated, affecting its muscle cells. While the study discusses the role of certain proteins in this condition, the main focus is on the diagnosis and immune response. Treatment details are not provided, but early diagnosis is crucial for managing infections like this.
People also search for: puppy muscle inflammation · Neospora caninum treatment · dog myositis symptoms
Abstract
Neosporosis was diagnosed in a 2-month-old dog by indirect immunofluorescence antibody test (IFAT) and confirmed by means of histopathology and immunohistochemistry. The associated myositis was characterized by Major Histocompatibility Complex expression on some muscle fibres. This finding indicates an immunological activation, of the muscle cells that, acquiring Major Histocompatibility Complex expression, may, in some way, contribute to antigen presentation. A possible role of these glycoproteins in the pathogenesis of Neospora-associated myositis is discussed.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15938572/