Peer-reviewed veterinary case report
Drug resistance proteins found in three dogs with lymphoma
By Hyokai, Sachiko et al.·Published in The Journal of veterinary medical science·2021·School of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Expression of P-glycoprotein and breast cancer resistance protein in three cases of canine lymphoma showing drug resistance.
- Species:
- dog
Plain-English summary
A dog with lymphoma was found to have drug resistance, making treatment difficult. Researchers looked at specific proteins in the dog's tumor that can block cancer medications from working effectively. They discovered that these proteins were not present before treatment but appeared after the dog received anticancer drugs. This suggests that the tumor's blood vessels may prevent the drugs from reaching the cancer cells, similar to how the brain protects itself from certain medications. Understanding this could help veterinarians find better ways to treat dogs with lymphoma in the future.
People also search for: dog lymphoma treatment · why is my dog's cancer not responding to medication · canine lymphoma drug resistance
Abstract
In canine lymphoma, drug resistance is the major factor hindering treatment. In this study, we performed immunohistochemical examination of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), which are considered as transporters related to multidrug resistance in three recurrent canine lymphomas. All cases were negative for both transporters before anticancer drug administration, but became positive after this administration. The expression was confirmed in capillary endothelial cells, such as in brain capillaries acting as the blood-brain barrier (BBB). It is suggested that both transporters expressed on capillary endothelial cells in lymphoma tissue may inhibit the spread of anticancer drugs into tumor tissues from blood, the same as the BBB. Therefore, capillary endothelial cells could act as a blood-tumor barrier, which might be involved in drug resistance in canine lymphoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33518631/