Peer-reviewed veterinary case report
Alpha-v integrin protein found in feline injection-site sarcoma tumors
By Andrea Cappelleri et al.·Published in Animals·2024·Department of Veterinary Medicine and Animal Sciences, University of Milan, 26900 Lodi, Italy, CH·View original on DOAJ →
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Original publication title: Expression of α<sub>v</sub> Integrin in Feline Injection-Site Sarcoma (FISS): Preliminary Investigations
- Species:
- cat
Plain-English summary
A cat with a malignant skin tumor called feline injection-site sarcoma (FISS) was studied to understand how a specific antibody could help evaluate the tumor's surgical removal. Researchers looked at tissue samples from cats with FISS and found that while the antibody didn't help determine if all the cancer was removed, it did show that certain cells in the tumor had a strong reaction to the antibody. This suggests that these cells might be involved in the tumor's development. Overall, the study highlights the complexity of treating FISS and the need for better methods to ensure complete removal of these tumors.
People also search for: cat injection-site sarcoma treatment · feline cancer surgery · signs of cat skin tumors
Abstract
Feline injection-site sarcomas (FISSs) are malignant skin tumors of mesenchymal origin arising at local post-vaccination (or injection) sites. In recent years, a fluorescence imaging technique based on probes targeting α<sub>v</sub>β<sub>3</sub> integrin has been effectively applied for the surgical complete resection of the tumor. In our study, we investigated the utility of a commercially available anti-α<sub>v</sub> integrin polyclonal antibody for the histopathological evaluation of FISS’s surgical excision margins. We collected 10 formalin-fixed paraffin-embedded (FFPE) feline excisional biopsies with a histopathological diagnosis of FISS (7 fibrosarcomas and 3 pleomorphic sarcomas) and wide margin tissue, along with one subcutaneous injection-site granuloma and 6 osteosarcomas. Samples were processed for histology, and slides were stained for IHC with the anti-α<sub>v</sub> integrin antibody. Immunostained slides were evaluated for the cellular localization and intensity of the staining in different neoplastic and non-neoplastic cell populations. Neoplastic and non-neoplastic spindle cells had cytoplasmic positivity in all fibrosarcomas. Inflammatory cells, including macrophages of the injection-site granuloma, were negative. Multinucleated giant cells in the pleomorphic sarcomas had an intense membranous positivity. Although the anti-α<sub>v</sub> integrin antibody was ineffective for the histopathological evaluation of surgical excision margins, the membranous localization of α<sub>v</sub> integrin in multinucleated giant cells of pleomorphic sarcomas suggests that it plays a role in the oncogenesis of this FISS variant.
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Search related cases →Original publication on DOAJ: https://doi.org/10.3390/ani14243588