Peer-reviewed veterinary case report
HMGA1 gene overexpressed in lymph nodes of dogs with lymphoma
By Joetzke, A E et al.·Published in Veterinary and comparative oncology·2010·Small Animal Clinic and Research Cluster of Excellence 'REBIRTH', Germany·View original on PubMed →
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Original publication title: Expression of the high mobility group A1 (HMGA1) and A2 (HMGA2) genes in canine lymphoma: analysis of 23 cases and comparison to control cases.
- Species:
- dog
Plain-English summary
A group of 23 dogs with lymphoma had their lymph node samples tested for specific gene expressions to see if they could help understand the disease better. The results showed that the HMGA1 gene was present in much higher amounts in the dogs with lymphoma compared to healthy dogs, while the HMGA2 gene levels were similar in both groups. This suggests that HMGA1 could be an important marker for diagnosing or understanding the prognosis of lymphoma in dogs. Further research may help determine how these genes can be used in treatment plans.
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Abstract
Overexpression of high mobility group A (HMGA) genes was described as a prognostic marker in different human malignancies, but its role in canine haematopoietic malignancies was unknown so far. The objective of this study was to analyse HMGA1 and HMGA2 gene expression in lymph nodes of canine lymphoma patients. The expression of HMGA1 and HMGA2 was analysed in lymph node samples of 23 dogs with lymphoma and three control dogs using relative quantitative real-time RT-PCR. Relative quantity of HMGA1 was significantly higher in dogs with lymphoma compared with reference samples. HMGA2 expression did not differ between lymphoma and control dogs. With the exception of immunophenotype, comparison of disease parameters did not display any differences in HMGA1 and HMGA2 expression. The present findings indicate a role of HMGA genes in canine lymphoma. This study represents the basis for future veterinary and comparative studies dealing with their diagnostic, prognostic and therapeutic values.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20579321/