Peer-reviewed veterinary case report
Dog developed fatal skin ulcers after drug treatment
By Schaefer, Laura et al.·Published in Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·2023·Small Animal Clinic, Germany·View original on PubMed →
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Original publication title: Extensive fatal Pyoderma gangrenosum in a dog after drug exposure.
- Species:
- dog
Plain-English summary
A 4-year-old spayed female mixed breed dog developed severe skin problems, including large, painful ulcers, after receiving a vaccination and treatment with certain medications. She also had a high fever and was very lethargic. Despite aggressive treatment with medications to suppress her immune system and fight infection, her condition worsened, leading to complications like breathing problems and fluid in her chest. Sadly, the dog was euthanized 16 days after being admitted to the veterinary clinic due to her severe health issues.
People also search for: dog skin ulcers after vaccination · pyoderma gangrenosum treatment in dogs · dog lethargy and fever after medication
Abstract
A 4-year-old, spayed female mixed breed dog was presented with large crater-like, well-demarcated, erosive and ulcerative necrotic lesions of the skin, elevated body temperature and lethargy, that began 14 days after vaccination and treatment with fluralaner and milbemycin/praziquantel. Cytology revealed severe pyogranulomatous inflammation with moderate numbers of extracellular microorganisms. Histopathologic examination showed severe multifocal pyogranulomatous dermatitis and panniculitis with severe dermal edema and severe neutrophilic exocytosis with band-like infiltration of the lower portion of the epidermis consistent with pyoderma gangrenosum. Despite intensive immunosuppressive and antimicrobial therapy and intensive inpatient care, the dog was euthanized 16 days after admission due to complications with clinical signs of sepsis, acute dyspnea and thoracic effusion.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37956667/