Peer-reviewed veterinary case report
Dog coughing and choking from laryngeal plasmacytoma tumor
By Witham, A I et al.·Published in New Zealand veterinary journal·2012·Institute of Veterinary·View original on PubMed →
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Original publication title: Extramedullary laryngeal plasmacytoma in a dog.
- Species:
- dog
Plain-English summary
An 8-year-old spayed female Border Collie was brought to the vet with a 3-week history of coughing, choking, and coughing up blood. After examining her throat, the vet found a mass on her larynx, which was diagnosed as a rare type of tumor called extramedullary plasmacytoma. The dog was treated with chemotherapy using melphalan and prednisolone, and her symptoms improved within a week, with the mass disappearing after a month. Unfortunately, the tumor returned after six months of treatment, and the owner chose to euthanize her, but there was no sign that the cancer had spread elsewhere in her body.
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Abstract
CASE HISTORY: An 8-year-old, female, spayed Border Collie presented with a 3-week history of coughing, choking and haemoptysis. CLINICAL FINDINGS: Inspiratory stridor was evident on clinical examination. Cervical radiographs revealed a round soft-tissue mass on the dorsal aspect of the epiglottis. A laryngeal mass was evident on examination under anaesthesia, and an incisional biopsy was obtained. Histopathology revealed a dense proliferation of neoplastic round cells morphologically consistent with plasma cell origin. Immunohistochemisty results were negative for CD3 (T cell marker) and positive for CD79a (B cell marker), resulting in a diagnosis of extramedullary plasmacytoma. The patient was treated with melphalan and prednisolone; clinical signs resolved within 1 week and the mass was no longer evident on laryngoscopy after 1 month of treatment. After 6 months of chemotherapy, the laryngeal mass recurred and euthanasia was requested. There was no evidence of systemic spread on post-mortem examination. DIAGNOSIS: Solitary extramedullary plasmacytoma of the canine larynx. CLINICAL RELEVANCE: Respiratory extramedullary plasmacytomas are extremely rare with only one laryngeal and two tracheal cases previously reported. This is the first published report of a laryngeal plasmacytoma that recurred despite combination chemotherapy with melphalan and prednisolone.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22175432/