Peer-reviewed veterinary case report
Dog with lymphoma causing right forelimb lameness and nerve swelling
By Ueno, Hiroshi et al.·Published in The Journal of veterinary medical science·2014·Department of Orthopedic and Neurosurgery, Japan·View original on PubMed →
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Original publication title: Extranodal lymphoma with peripheral nervous system involvement in a dog.
- Species:
- dog
Plain-English summary
An 8-year-old female Cavalier King Charles spaniel was brought in for worsening lameness in her right front leg. Tests, including an MRI, showed swelling in her nerves, and a biopsy confirmed she had T-cell lymphoma, a type of cancer. The dog was treated with a combination of chemotherapy and radiation, but unfortunately, the treatment did not work. After her passing, a necropsy revealed that the cancer had spread to her spinal cord, liver, pancreas, and kidneys, indicating a severe progression of the disease.
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Abstract
An 8-year-old neutered female Cavalier King Charles spaniel was evaluated for progressing right forelimb lameness. Magnetic resonance imaging revealed that the right-side radial nerves and the caudal brachial plexus were swollen. The histological and molecular biological diagnosis by partial biopsy of the C8 spinal nerve was T-cell lymphoma. Coadministration of lomustine and irradiation was started. However, this therapy was ineffective. At necropsy, neoplastic tissues were seen extending into the subarachnoid space of the spinal cord, liver, pancreas and kidneys as gross findings. A large mass was also identified occupying the caudal thorax. Histologic findings included infiltration in these organs and the mass by neoplastic lymphocytes. To date, involvement of peripheral nerves (neurolymphomatosis) is rarely reported in veterinary species.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24419974/