Peer-reviewed veterinary case report
Pamidronate injection site reactions in 11 dogs with bone tumors
By Marker, B A et al.·Published in Veterinary and comparative oncology·2017·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Extravasation reactions associated with the administration of pamidronate: 11 cases (2008-2013).
- Species:
- dog
Plain-English summary
A group of 11 dogs receiving pamidronate, a medication used for bone tumors, experienced tissue damage when the drug leaked out of their veins. Most of these reactions were mild, but one dog had a severe reaction that led to euthanasia. The time it took for the affected areas to heal varied, with some dogs recovering in just a few days, while others took over a month. Although the extravasation reactions can be serious, most dogs did not have long-lasting issues after treatment.
People also search for: dog bone tumor treatment · pamidronate side effects in dogs · dog intravenous medication complications
Abstract
Pamidronate is a bisphosphonate drug widely utilized in veterinary oncologic practice for the palliation of malignant osteolysis. Pamidronate has not been previously reported to cause tissue injury upon extravasation in dogs. The medical records of 11 client-owned dogs undergoing palliative treatment for primary bone tumors with known or suspected pamidronate extravasation reactions were reviewed. The majority of adverse events were low grade in nature, however in some cases, the reactions were severe and led to euthanasia in one instance. Time to complete resolution of lesions ranged from within several days to greater than one and a half months. Aside from the dog that was euthanized, no long-term sequelae of extravasation were identified. Treatments employed to address the reactions varied widely. Pamidronate extravasation reaction appears to be an uncommon, but potentially serious complication of intravenous administration.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27174040/