Peer-reviewed veterinary case report
What affects survival time in dogs with chronic kidney disease
By Rudinsky, Adam J et al.·Published in Journal of veterinary internal medicine·2018·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Factors associated with survival in dogs with chronic kidney disease.
- Species:
- dog
Plain-English summary
A group of 27 dogs with chronic kidney disease (CKD) were studied to understand what factors might affect how long they live. The researchers found that certain signs, like low body condition score, muscle loss, high creatinine levels, and increased levels of a protein called FGF-23, were linked to shorter survival times. Dogs in more advanced stages of CKD also had significantly different survival times. This suggests that monitoring these factors, especially FGF-23, could help veterinarians predict how long a dog with CKD might live and guide treatment decisions.
People also search for: dog chronic kidney disease survival · FGF-23 in dogs · signs of kidney disease in dogs · dog kidney disease treatment options
Abstract
BACKGROUND: Chronic kidney disease (CKD) is associated with morbidity and mortality in dogs. Plasma fibroblast growth factor-23 (FGF-23) concentration is an independent predictor of CKD progression and survival in cats and people with CKD. OBJECTIVES: To investigate the relationship among FGF-23, parathyroid hormone (PTH), vitamin D metabolites, and other clinical variables with survival time in dogs with CKD. ANIMALS: Twenty-seven azotemic CKD dogs. METHODS: Dogs were recruited prospectively into the study and followed until death or study conclusion. Dogs were International Renal Interest Society (IRIS) staged into stage 2 (n = 9), stage 3 (n = 12), and stage 4 (n = 6) CKD. Survival times were calculated from the date of study inclusion. Univariable Cox regression was used to assess variables associated with survival including body condition score (BCS), muscle condition score, hematocrit, creatinine, CKD stage, serum phosphorus, urine protein:creatinine ratio (UPC), calcium phosphorus product (CaPP), PTH, 25-hydroxyvitamin D, 1,25--dihydroxyvitamin D, and FGF-23 concentrations. RESULTS: Significant hazard ratios (hazard ratio; 95% confidence interval; P value) were as follows: BCS < 4/9 (1.579; 1.003-2.282; P = .05), muscle atrophy (2.334; 1.352-4.030; P = .01), increased creatinine (1.383; 1.16-1.64; .01), hyperphosphatemia (3.20; 1.357-7.548; P = .005), increased UPC (3.191; 1.310-7.773; P = .01), increased CaPP (4.092; 1.771-9.454; P = .003), and increased FGF-23 (2.609; 1.090-6.240; P = .05). Survival times for each IRIS CKD stage were significantly different (P = .01). CONCLUSIONS AND CLINICAL IMPORTANCE: Multiple variables, including FGF-23, were associated with duration of survival in CKD dogs. FGF-23 could be a prognostic marker in dogs with CKD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30325060/