Peer-reviewed veterinary case report
Why dogs with leishmaniasis get nosebleeds and what causes them
By Petanides, T A et al.·Published in Journal of veterinary internal medicine·2008·Companion Animal Clinic·View original on PubMed →
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Original publication title: Factors associated with the occurrence of epistaxis in natural canine leishmaniasis (Leishmania infantum).
- Species:
- dog
Plain-English summary
A group of 51 dogs with leishmaniasis, a disease caused by a parasite, was studied to understand why some had nosebleeds (epistaxis) while others did not. The dogs with nosebleeds showed signs of several health issues, including higher levels of certain proteins in their blood and problems with their platelets, which help with blood clotting. These findings suggest that the nosebleeds could be due to a combination of factors like blood abnormalities and damage to the nasal lining. Understanding these connections can help veterinarians better manage and treat dogs suffering from leishmaniasis and its complications.
People also search for: dog nosebleed causes · canine leishmaniasis treatment · why is my dog bleeding from the nose
Abstract
BACKGROUND: Canine leishmaniasis (CanL) is a common cause of epistaxis in dogs residing in endemic areas. The pathogenesis of CanL-associated epistaxis has not been fully explored because of the limited number of cases reported so far. HYPOTHESIS: Epistaxis in CanL could be attributed to more than 1 pathomechanism such as hemostatic dysfunction, biochemical abnormalities, chronic rhinitis, and coinfections occurring in various combinations. ANIMALS: Fifty-one dogs with natural CanL. METHODS: The allocation of 51 dogs in this cross-sectional study was based on the presence (n = 24) or absence (n = 27) of epistaxis. The potential associations among epistaxis and concurrent infections (Ehrlichia canis, Bartonella spp., and Aspergillus spp.), biochemical and hemostatic abnormalities, and nasal histopathology were investigated. RESULTS: Hypergammaglobulinemia (P= .044), increased serum viscosity (P= .038), decreased platelet aggregation response to collagen (P= .042), and nasal mucosa ulceration (P= .039) were more common in the dogs with epistaxis than in those without epistaxis. The other significant differences between the 2 groups involved total serum protein (P= .029) and gamma-globulin (P= .013) concentrations, which were higher, and the percentage platelet aggregation to collagen, which was lower (P= .012) in the epistaxis dogs. CLINICAL IMPORTANCE: CanL-associated epistaxis appears to be the result of multiple and variable pathogenetic factors such as thrombocytopathy, hyperglobulinemia-induced serum hyperviscosity, and nasal mucosa ulceration.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18564224/