Peer-reviewed veterinary case report
Risk factors for blood clots in dogs with kidney protein loss
By Fortuna, Luca & Syme, Harriet M·Published in Journal of veterinary internal medicine·2024·Department of Clinical Science and Services, United Kingdom·View original on PubMed →
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Original publication title: Factors associated with thrombotic disease in dogs with renal proteinuria: A retrospective of 150 cases.
- Species:
- dog
Plain-English summary
A group of 150 dogs with kidney issues causing protein in their urine were studied, and 50 of these dogs also had thrombotic disease, which can lead to blood clots. The Cavalier King Charles Spaniel breed was found to be particularly at risk for developing this condition. Dogs with thrombotic disease had higher levels of certain white blood cells and lower levels of a protein called albumin in their blood compared to those without the disease. Understanding these differences can help veterinarians better manage and treat dogs with kidney problems and associated thrombotic disease.
People also search for: dog kidney disease symptoms · Cavalier King Charles Spaniel blood clot risk · treatment for dog proteinuria
Abstract
BACKGROUND: Knowledge of additional risk factors for thrombotic disease (TD) among dogs with renal proteinuria is limited; these might differ for TD affecting the systemic arterial (AT), systemic venous (VT), and pulmonary circulation (PT). HYPOTHESIS/OBJECTIVES: To compare signalment and clinicopathological data between dogs with renal proteinuria with or without TD, and between dogs with AT, VT, and PT. ANIMALS: One hundred fifty client-owned dogs with renal proteinuria, 50 of which had TD. METHODS: Retrospective case-controlled study. A database search (2004-2021) identified proteinuric dogs (UPC > 2) with and without TD. Clinicopathological data were obtained from the records. TD and non-TD (NTD) groups were compared by binary logistic regression, and AT, VT, and PT groups by multinomial regression. Normal data presented as mean ± SD, non-normal data presented as median [25th, 75th percentiles]. RESULTS: Cavalier King Charles Spaniels were overrepresented in the TD group (OR = 98.8, 95% CI 2.09-4671, P = .02). Compared to NTD cases, TD cases had higher concentration of neutrophils (11.06 [8.92, 16.58] × 10/L vs 7.31 [5.63, 11.06] × 10/L, P = .02), and lower concentration of eosinophils (0 [0, 0.21] × 10/L vs 0.17 [0.04, 0.41] × 10/L, P = .002) in blood, and lower serum albumin (2.45 ± 0.73 g/dL vs 2.83 ± 0.73 g/dL, P = .04). AT cases had higher serum albumin concentrations than VT cases (2.73 ± 0.48 g/dL vs 2.17 ± 0.49 g/dL, P = .03) and were older than PT cases (10.6 ± 2.6 years vs 7.0 ± 4.3 years, P = .008). VT cases were older (9.1 ± 4.2 years vs 7.0 ± 4.3 years, P = .008) and had higher serum cholesterol concentration (398 [309-692 mg/dL] vs 255 [155-402 mg/dL], P = .03) than PT cases. CONCLUSIONS AND CLINICAL IMPORTANCE: Differences between thrombus locations could reflect differences in pathogenesis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38147488/