Peer-reviewed veterinary case report
What affects treatment success in dogs with eosinophilic
By De Simoi, Vanessa et al.·Published in Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·2023·Medizinische Kleintierklinik Mü·View original on PubMed →
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Original publication title: Factors influencing the response to therapy in dogs with eosinophilic bronchopneumopathy.
- Species:
- dog
Plain-English summary
A group of dogs with breathing problems, specifically eosinophilic bronchopneumopathy (EBP), were studied to understand what factors affect their response to treatment. The research found that dogs who showed symptoms for a longer time before starting treatment were less likely to recover fully. Additionally, those with more specific types of white blood cells in their lung fluid were more likely to have ongoing issues. The key takeaway is that getting a diagnosis and starting treatment early can significantly improve the chances of recovery for dogs with this condition.
People also search for: dog breathing problems treatment · eosinophilic bronchopneumopathy in dogs · early treatment for dog respiratory issues
Abstract
OBJECTIVES: Canine eosinophilic bronchopneumopathy (EBP) is a poorly understood disease characterized by chronic inflammation of the lower airways. To date, factors affecting the course of the disease are largely unknown. The objective of this study was to investigate the influence of clinical, laboratory, and environmental factors on therapeutic outcome in dogs with EBP. MATERIAL AND METHODS: Environmental and housing conditions, course of disease, and response to treatment were evaluated using a standardized questionnaire for owners of 29 dogs diagnosed with EBP from 3 different veterinary referral centers in Germany. Data of diagnostic tests (hematology, radiographs, bronchoalveolar-lavage-fluid-(BALF) cytology) were retrospectively obtained from medical records. The influence of the different factors was assessed using Fisher's-exact-test and Mann-Whitney-U- or Kruskal-Wallis-test. RESULTS: The proportion of neutrophilic granulocytes in BALF-cytology was significantly higher in dogs with persistent clinical signs compared to dogs that achieved clinical remission (p=0.029). Duration of clinical signs before treatment was significantly longer in dogs with persistent clinical signs (16±12 months) compared to dogs that achieved clinical remission (6±7 months) (p=0.017). CONCLUSION: Early diagnosis and therapy have a decisive influence on the success of treatment. CLINICAL RELEVANCE: Dogs with respiratory signs suspicious for EBP should be evaluated in a timely manner to increase the likelihood of clinical remission with an early start of therapy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36917989/