Peer-reviewed veterinary case report
Differences in gut bacteria in dogs with multicentric lymphoma
By Gavazza, A et al.·Published in Veterinary and comparative oncology·2018·School of Biosciences and Veterinary Medicine, Italy·View original on PubMed →
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Original publication title: Faecal microbiota in dogs with multicentric lymphoma.
- Species:
- dog
Plain-English summary
A group of dogs with multicentric lymphoma (a type of cancer) showed significant differences in their gut bacteria compared to healthy dogs. Researchers found that dogs with lymphoma had lower levels of certain beneficial bacteria and higher levels of harmful bacteria in their feces. This imbalance in gut bacteria, known as dysbiosis, was notably higher in the lymphoma-affected dogs. Understanding these changes could help in managing the health of dogs with this type of cancer, but further research is needed to see how these findings might influence treatment or outcomes.
People also search for: dog lymphoma gut bacteria · canine cancer gut health · dog fecal microbiota changes
Abstract
Malignant lymphoma B-cell type is the most common canine haematopoietic malignancy. Changes in intestinal microbiota have been implicated in few types of cancer in humans. The aim of this prospective and case-control study was to determine differences in faecal microbiota between healthy control dogs and dogs with multicentric lymphoma. Twelve dogs affected by multicentric, B-cell, stage III-IV lymphoma, and 21 healthy dogs were enrolled in the study. For each dog, faecal samples were analysed by Illumina sequencing of 16S rRNA genes and quantitative PCR (qPCR) for selected bacterial groups. Alpha diversity was significant lower in lymphoma dogs. Principal coordinate analysis plots showed different microbial clustering (P = .001) and linear discriminant analysis effect size revealed 28 differentially abundant bacterial groups in lymphoma and control dogs. The qPCR analysis showed significant lower abundance of Faecalibacterium spp. (q < .001), Fusobacterium spp. (q = .032), and Turicibacter spp. (q = .043) in dogs with lymphoma compared with control dogs. On the contrary, Streptococcus spp. was significantly higher in dogs with lymphoma (q = .041). The dysbiosis index was significantly higher (P < .0001) in dogs with lymphoma. In conclusion, both sequencing and qPCR analyses provided a global overview of faecal microbial communities and showed significant differences in the microbial communities of dogs presenting with multicentric lymphoma compared with healthy control dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29152844/