Peer-reviewed veterinary case report
Labrador retriever with Fanconi syndrome causing excessive thirst
By Settles, E L & Schmidt, D·Published in Journal of veterinary internal medicine·1994·Department of Small Animal Medicine and Surgery·View original on PubMed →
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Original publication title: Fanconi syndrome in a Labrador retriever.
- Species:
- dog
Plain-English summary
A 2-year-old male Labrador Retriever was brought to the vet because he was drinking a lot of water, urinating frequently, and showing signs of joint or muscle pain. Tests revealed that he had low levels of urea in his blood and high levels of protein in his urine, indicating a kidney issue known as Fanconi syndrome. This condition affects how the kidneys handle certain nutrients, leading to the loss of important amino acids. While the study suggests that understanding these kidney transport issues could lead to better treatments in the future, specific treatment outcomes for this dog were not detailed.
People also search for: Labrador Retriever kidney disease symptoms · dog excessive thirst and urination · Fanconi syndrome treatment in dogs
Abstract
A 2-year-old male Labrador Retriever was presented to the University of Missouri Veterinary Teaching Hospital with the primary complaints of polydipsia, polyuria, and joint or muscle pain. Low blood urea nitrogen concentration, hyperchloremia, and marked proteinuria were the only abnormalities in a serum biochemical profile and urinalysis. Decreased creatinine clearance and increased renal fractional excretion of sodium, potassium, calcium, and phosphorus were detected by renal clearance studies. Increased excretion of most amino acids was found by amino acid analysis of urine, but not all amino acids were lost with equal magnitude. Amino acids with secondary amino groups or basic side chains were lost at increased rates, whereas those with acidic side chains were not. These differences could be related to defects in specific renal amino acid transport mechanisms. Identification of these transport mechanisms may allow for pharmacologic intervention at the point of renal loss to alleviate clinical signs of disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/7884724/