Peer-reviewed veterinary case report
Fascin-1 expression in canine cutaneous and oral melanocytic tumours.
- Journal:
- Veterinary and comparative oncology
- Year:
- 2012
- Authors:
- Yamada, N et al.
- Affiliation:
- United Graduate School of Veterinary Sciences · Japan
- Species:
- dog
Abstract
Fascin-1 expression was examined in 9 cutaneous melanocytomas and 47 oral melanomas. The cases were scored on the basis of extent and intensity of staining, and combined scores were calculated. Fascin-1 expression was observed in 5/9 (56%) melanocytomas and 46/47 (98%) melanomas. The combined score for fascin-1 was significantly greater in stage III/IV melanomas than in stage I/II melanomas (P < 0.05). In addition, strong fascin-1 staining was associated with a significantly shortened survival time (P < 0.05). The results of this study suggest that fascin-1 overexpression correlates with the malignancy of canine melanoma and has the potential to be a new immunohistochemical marker to predict the clinical course of canine melanoma. In addition, targeted therapy for fascin-1 may represent a new strategy for the treatment of canine melanoma.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22236355/