Peer-reviewed veterinary case report
Prognosis factors in dogs with rare bone-like oral melanoma
By Sánchez, J et al.·Published in Veterinary pathology·2007·Departamento de Anatomí, Spain·View original on PubMed →
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Original publication title: Immunohistochemical characterization and evaluation of prognostic factors in canine oral melanomas with osteocartilaginous differentiation.
- Species:
- dog
Plain-English summary
A 10-year-old dog was diagnosed with an oral melanoma, a type of cancer that is common in dogs. This particular case had a rare feature called osteocartilaginous differentiation, which means the tumor had some bone-like characteristics. The vet examined the tumor's behavior and found that it reacted positively to certain tests, indicating it was a melanoma. The study suggested that the growth and spread of this type of melanoma are similar to other oral melanomas, and certain tests could help predict how aggressive the cancer might be.
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Abstract
Melanomas are the most common malignant oral neoplasm in dogs. Osteocartilaginous differentiation in oral melanomas is a rare feature described both in veterinary and human medicine. Here, 10 cases of this type of neoplasm were used to study their immunohistochemical, biological, and clinical characteristics. Reactivity for S100 and melan A antigen was evaluated, and 4 prognosis factors (mitotic index, invasiveness of epithelium, nuclear atypia, and proliferation index) were analyzed and correlated with the clinical course of the neoplasms after diagnosis. Immunohistochemical analysis of the studied neoplasms, including the osteocartilaginous areas, showed positive immunoreaction for S100 and melan A, except in one dog, which was negative for melan A. Analysis of the results showed that oral melamonas with osteocartilaginous differentiation have a clinical course similar to that of other melanomas in the oral cavity. Analysis of the mitotic index and the expression of proliferation marker Ki-67 could be useful tools for predicting the biological behavior of these neoplasms.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17846240/