Peer-reviewed veterinary case report
Fasting lowers side effects of vincristine chemo in dogs
By Duckett, Margaret E et al.·Published in Veterinary and comparative oncology·2021·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Fasting reduces the incidence of vincristine-associated adverse events in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with cancer receiving vincristine chemotherapy were fasted for 24 to 28 hours before and 6 hours after their treatment to see if it would help reduce side effects like nausea, loss of appetite, and lethargy. The results showed that fasting significantly lowered these symptoms compared to when the dogs were fed normally. This approach was found to be safe and effective, helping the dogs feel better during their treatment.
People also search for: dog cancer treatment side effects · vincristine nausea in dogs · fasting before chemotherapy for dogs
Abstract
Fasting has been shown to decrease chemotherapy-associated adverse events (AEs), in part through insulin-like growth factor (IGF-1) reduction, and may induce a protective effect on normal cells during chemotherapy treatment in mice and people. The purpose of this study was to evaluate the effect of fasting on constitutional, bone marrow and gastrointestinal (GI) AEs, and serum glucose, IGF-1 and insulin levels in dogs receiving vincristine. The study was a prospective, crossover clinical trial in tumour-bearing dogs. Dogs were randomized to be fasted for 24 to 28 hours prior to and 6 hours following their first or second vincristine treatment, and fed normally for the alternate dose. A significant reduction in nausea, anorexia, lethargy and serum insulin was observed when dogs were fasted; however, no significant differences were found in other GI symptoms, neutrophil count, serum glucose or IGF-1. Fasting prior to vincristine therapy is a safe and effective treatment modality that helped mitigate constitutional and GI AEs in tumour-bearing dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33448618/