Peer-reviewed veterinary case report
Fecal microbiome differences in dogs with IBD and intestinal lymphoma
By Omori, Marie et al.·Published in The Journal of veterinary medical science·2017·Department of Veterinary Clinical Pathobiology, Japan·View original on PubMed →
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Original publication title: Fecal microbiome in dogs with inflammatory bowel disease and intestinal lymphoma.
- Species:
- dog
Plain-English summary
A group of dogs with gastrointestinal issues, including eight with inflammatory bowel disease (IBD) and eight with intestinal lymphoma, had their fecal samples analyzed to understand the differences in gut bacteria. The study found that dogs with intestinal lymphoma had a different mix of bacteria compared to those with IBD and healthy dogs. Specifically, certain bacteria were more common in dogs with lymphoma, while others were more prevalent in dogs with IBD. These findings suggest that changes in gut bacteria could be linked to both conditions, which may help veterinarians in diagnosing and treating these diseases in dogs.
People also search for: dog inflammatory bowel disease symptoms · dog intestinal lymphoma treatment · changes in dog gut bacteria
Abstract
Although alteration of commensal microbiota is associated with chronic gastrointestinal (GI) diseases such as inflammatory bowel disease (IBD) in dogs, the microbiota composition in intestinal lymphoma, an important differential diagnosis of canine IBD, has not been investigated. The objective of this study was to compare the fecal microbiota in dogs with IBD, dogs with intestinal lymphoma, and healthy dogs. Eight dogs with IBD, eight dogs with intestinal lymphoma, and fifteen healthy dogs were included in the study. Fecal samples were analyzed by 16S rRNA gene next-generation sequencing. Rarefaction analysis failed to reveal any difference in bacterial diversity among healthy dogs and diseased dogs. Based on PCoA plots of unweighted UniFrac distances, the bacterial composition in dogs with intestinal lymphoma was different from those observed in dogs with IBD and healthy dogs. When compared with healthy dogs, intestinal lymphoma subjects showed significant increases in organisms belonging to the Eubacteriaceae family. The proportion of the family Paraprevotellaceae and the genus Porphyromonas was significantly higher in dogs with IBD compared to healthy dogs. These observations suggest that dysbiosis is associated with intestinal lymphoma as well as IBD in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28993566/